Aerobic training and lipid profile of hypothyroid rats

  • L. Tonello Postgraduate Physical Education Program. Universidade Católica de Brasília (UCB). Águas Claras - DF. Brazil.
  • D. Bueno Godinho Ribeiro Physical Education and Physiotherapy. Centro Universitário UnirG. Gurupi, Tocantins. Brazil.
  • R. Yukio Asano Postgraduate Physical Education Program. Universidade Católica de Brasília (UCB). Águas Claras - DF. Brazil. Physical Education and Physiotherapy. Centro Universitário UnirG. Gurupi, Tocantins. Brazil.
  • J. Marques da Silveira Masters in Rehabilitation with an emphasis on Cardiovascuçar and Respiratory Physiotherapy. Department of Physiotherapy and Medicine. Centro Universitário UnirG. Gurupi, Tocantins. Brazil.
  • E. Fernandes de Miranda Centro Universitário UnirG. Gurupi, Tocantins. Brazil. Laboratory of Biosciences of Human Motricity (LABIMH) of the Federal University of Rio de Janeiro State (UNIRIO). Rio de Janeiro - Brazil.
Keywords: Hipotiroidismo, Ejercicio, Metabolismo de los lípidos, Lipoproteínas Hypothyroidism, Exercise, Lipid metabolism, Lipoproteins Hipotireoidismo, Exercício, Metabolismo lipídico, Lipoproteínas

Abstract

 

Objective. The objective of this study was to investigate the effects of 17 weeks of swimming exercise on the lipid profile of hypothyroid rats.

Method. 24 male Wistar rats were divided into four groups: controls submitted to aerobic training (CT); hypothyroid submitted to aerobic training (HT); sedentary controls (SC) and sedentary hypothyroid (SH). HT and SH were induced to hypothyroidism by administering 1 mg of propylthiouracil, while CT and SC animals received distilled water. The animals had unrestricted access to ration and water. Swimming took place five times per week, 60 minutes per session, with overload corresponding to 3% of body weight. At the end of the experiment total cholesterol (C), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), very low-density lipoprotein (VLDL-C), triglycerides and thyroid stimulating hormone (TSH) levels were measured.

Results. The main finding of the study was the lower values (p < 0.05) obtained for two variables in the HT group (C = 74.6 ± 8.7 mg/dl and LDL = 43.7 ± 6.5 mg/dl) compared to the SH group (C = 91.3 ± 6.8 mg/dl and LDL-C = 55.6 ± 2.0 mg/dl).

Conclusion. It was concluded that swimming exercises can minimize the increase in C and LDL-C blood levels in hypothyroid rats.

 
 
Published
2018-05-01
Issue
Vol. 6 No. 2 (2013): June 2013
Section
Originals
Page/s
47-51