Effect of cryotherapy on the concentration of interleukin 6 induced by physical exercise:

a systematic review

  • Bianca Veronese da Silva
  • Mayara Louise Beltrame
  • Dérrick Patrick Artioli
  • Márcia Rosângela Buzanello
  • Gladson Ricardo Flor Bertolini Universidade Estadual do Oeste do Paraná
DOI: https://doi.org/10.33155/ramd.v18i3.1202
Keywords: Cold therapy, exercise-induced muscle damage, muscle injury, interleukins Crioterapia, daño muscular inducido por el ejercicio, lesión muscular, interleucinas Crioterapia, dano muscular induzido pelo exercício, lesão muscular, interleucinas

Abstract

The aim of this study was carry out a literature review on the effect of cryotherapy on the concentration of interleukin 6 induced by physical exercise. The databases included were PubMed, Cochrane, the Physiotherapy Evidence Database (PEDro), Scopus, Web Of Science and LILACS. Also gray literature: Google Scholar, LIVIVO, Open Grey and Banco de Teses e Dissertações da CAPES. The risk of bias was assessed using the Cochrane tool, RoB 2. The outcome was the concentration of interleukin 6. Two randomized controlled trials were selected from 8573 records. The overall risk of bias was of some concern in both studies. One suggests that cold water immersion (CWI) can reduce interleukin-6 (IL-6) levels during intense training. The other found that whole-body cryotherapy (WBC) and CWI versus passive recovery after a single run, with interventions at different times after exercise, had no significant interaction between group and time in significantly increasing IL-6 levels.

Published
2026-01-08
Issue
Vol. 18 No. 3 (2025): September 2025
Section
Revisiones
DOI
https://doi.org/10.33155/ramd.v18i3.1202