Role of cardiorespiratory fitness on the associations between endocannabinoid system and depressive symptoms in adults diagnosed with depression: the SONRIE study

  • Manuel Ruiz-Muñoz 1-MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz, Spain. 2-Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, Spain.
  • Sonia Ortega-Gómez 1-MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz, Spain. 2-Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, Spain.
  • David Jiménez-Pavón 1-MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz, Spain. 2-Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, Spain.
  • Maria del Mar Espinosa-Nogales Mental Health Clinical Management Unit, Puerto Real University Hospital, Cádiz, Spain.
  • Miguel Ángel Rosety-Rodríguez 1-MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz, Spain. 2-Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, Spain.
  • Vanesa España-Romero 1-MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz, Spain. 2-Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital, Spain.
DOI: https://doi.org/10.33155/j.ramd.2022.08.001
Keywords: Trastorno depresivo, Sistema endocannabinoide, Capacidad cardiorrespiratoria Depressive disorder, Endocannabinoid system, cardiorespiratory fitness Desordem depressiva, Sistema endocannabinoide, Aptidão cardiorrespiratória

Abstract

Objective: Endocannabinoid system (ES) seems to be altered in patients with depression. Cardiorespiratory fitness (CRF) may be an interacting factor in the relationship between ES biomarkers and depressive symptoms in people diagnosed with depression. The aim was to study the role of CRF on the possible association between ES biomarkers and depressive symptoms in 73 adults diagnosed with depression.

Method: This study examine the outcomes of cardiorespiratory fitness and plasma levels of the lipid mediators; anandamide (AEA) and 2-arachidonoylglycerol (2-AG) sampled from 73 adults diagnosed with depression.

Results: Patients with high CRF level had significant and inverse association among depressive symptoms and 2-AG serum levels (β: -0.013; 95% CI: -0.262 to -0.000; R²=22.6; P<0.001).

Conclusions: Higher CRF levels could have a protective role on depressive symptoms by increases in 2-AG.

Published
2022-08-04
Issue
Vol. 15 No. 3 (2022): September 2022
Section
Originals
Page/s
93-96
DOI
https://doi.org/10.33155/j.ramd.2022.08.001